RT Book, Section
A1 White, Lucile E.
A1 Levy, Ross M.
A1 Alam, Murad
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56063652
T1 Chapter 127. Neoplasias and Hyperplasias of Muscular and Neural Origin
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56063652
RD 2024/04/18
AB The  dermis  contains  smooth  muscle  fibers  in  the  arrector  pili  muscles,  in  the  walls  of  dermal  blood  vessels,  and  in  the  dartos  muscle  of  the  scrotum,  vulva,  nipple,  and  areola.  There  are  three  types  of  cutaneous  smooth  muscle  lesions:  (1)  leiomyomas,  (2)  leiomyosarcomas,  and  (3)  hamartomas.  Smooth  muscle  is  recognized  histologically  by  spindle  cell  shape,  eosinophilic,  fibrillary  cytoplasm,  and  blunt-ended,  oval,  “cigar-shaped”  nuclei.  On  immunohistochemical  staining,  cells  express  smooth  muscle  actin  and  the  muscle-specific  intermediate  filament  desmin,  but  are  negative  for  S100  protein  and  epithelial  membrane  antigen  (EMA).