RT Book, Section
A1 Bailey, Evans C.
A1 Sober, Arthur J.
A1 Tsao, Hensin
A1 Mihm, Martin C.
A1 Johnson, Timothy M.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56062430
T1 Chapter 124. Cutaneous Melanoma
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56062430
RD 2023/09/30
AB |PrintMelanoma  at  a  GlanceRising  incidence  worldwide;  United  States  estimated  lifetime  risk  of  developing  invasive  melanoma  is  1:1,500  if  born  in  1935,  1:600  if  born  in  1960,  1:62  if  born  in  2006,  and  1:50  if  born  in  2010  (1:30  with  inclusion  of  in  situ  melanoma).Risk  factors  include  history  of  sunburns  and/or  heavy  sun  exposure,  blue  or  green  eyes,  blonde  or  red  hair,  fair  complexion,  >100  typical  nevi,  any  atypical  nevi,  prior  personal  or  family  history  of  melanoma,  or  p16  mutation.Mean  age  of  diagnosis  is  52  years,  10–15  years  younger  than  other  more  common  cancers  of  the  breast,  lung,  colon,  and  prostate.Most  common  location  is  the  back  for  men,  and  lower  extremities  followed  by  trunk  for  women  but  can  occur  anywhere  on  the  skin  surface.Features  used  for  melanoma  recognition:  A  (asymmetry),  B  (irregular  borders),  C  (color  variegation),  D  (diameter  >6  mm  in  most  common  use,  but  others  have  changed  D  to  difference—“ugly  duckling”  sign  or  different  with  respect  to  change  in  size,  shape,  color,  or  persistent  lesional  pruritus),  and  E  (evolving  over  time).Follows  a  highly  variable  course  and  represents  a  heterogeneous  disorder;  surgically  curable  if  diagnosed  and  treated  in  early  phase,  but  potentially  lethal  with  increased  risk  when  diagnosed  and  treated  late.