RT Book, Section
A1 Rünger, Thomas M.
A1 Kraemer, Kenneth H.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56057161
T1 Chapter 110. Genome Instability, DNA Repair, and Cancer
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56057161
RD 2024/04/23
AB |PrintGenome  Instability,  DNA  Repair,  and  Cancer  at  a  GlanceDNA  can  be  damaged  by  physical  agents  (ultraviolet  or  ionizing  radiation)  or  chemical  agents  in  the  environment.DNA  damage  may  lead  to  mutations  (changes  in  DNA  sequence).The  ability  of  cells  to  repair  DNA  damage  and  to  maintain  genome  stability  is  of  utmost  importance  to  prevent  malignant  transformation.Different  agents  induce  different  types  of  DNA  damage,  which  in  turn  require  different  responses  and  repair  pathways.A  number  of  hereditary  disorders  are  characterized  by  genome  instability  due  to  defects  in  genes  involved  in  DNA  repair  or  DNA  damage  signaling.Many  different  laboratory  tests  can  be  used  to  diagnose  genome  instability  and/or  DNA  repair  defects.Inherited  or  acquired  genome  instability  is  associated  with  an  increased  cancer  risk.