RT Book, Section
A1 Mauro, Theodora M.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56047872
T1 Chapter 83. Biology of Eccrine and Apocrine Glands
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56047872
RD 2024/10/15
AB |PrintSweating  at  a  GlanceHumans  have  2–24  million  sweat  glands.Up  to  10  L/day  of  sweat  is  produced  by  acclimatized  individuals.The  three  eccrine  cell  types  are  (1)  clear  (secretory),  (2)  dark  (mucoid),  and  (3)  myoepithelial  (contractile).Hypothalamic  temperature  is  the  strongest  stimulus  for  sweating.Acetylcholine  is  the  major  stimulus  secreted  by  sympathetic  nerves.Botulinum  toxin  inhibits  sweating  by  preventing  acetylcholine  release.Oxidative  metabolism  of  glucose  is  a  major  source  of  eccrine  gland  adenosine  triphosphate.Ductal  reabsorption  conserves  NaCl.In  individuals  with  cystic  fibrosis,  mutated  chloride  channels  increase  NaCl  loss.Bacteria  are  necessary  for  apocrine  odor.Odiferous  precursors  secretion  is  controlled  by  the  MRP8  encoded  by  ABCC11.Adrenergic  stimulation  controls  apocrine  gland  secretion.