RT Book, Section
A1 Hengge, Ulrich R.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56040547
T1 Chapter 65. Lichen Sclerosus
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56040547
RD 2024/04/25
AB |PrintLichen  Sclerosus  at  a  GlanceInfrequent  chronic  inflammatory  dermatosis  with  anogenital  and  extragenital  manifestations.Preferentially  affects  women  in  the  fifth  or  sixth  decade  of  life  and  children  younger  than  the  age  of  10  years;  gender  ratio  5:1  female–male.Antibodies  to  extracellular  matrix  protein-1  and  T  cells  with  receptor  rearrangement  point  to  an  autoimmune  pathogenesis.Anogenital  manifestations  cause  severe  discomfort  (pruritus,  dyspareunia,  dysuria,  and  painful  defecation)  and  present  with  polygonal  papules  and  porcelain-white  plaques,  erosions,  and  various  degrees  of  sclerosis.Vulvar  lichen  sclerosus  is  associated  with  an  increased  risk  of  squamous  cell  carcinoma;  the  role  of  human  papillomavirus  infection  or  prior  radiotherapy  remains  to  be  elucidated.Potent  topical  corticosteroids  and  skin  care  are  the  most  successful  therapeutics;  calcineurin  antagonists  have  also  recently  demonstrated  benefit.Interdisciplinary  management  is  essential  for  long-term  control.