RT Book, Section
A1 Krieg, Thomas
A1 Aumailley, Monique
A1 Koch, Manuel
A1 Chu, Mon-Li
A1 Uitto, Jouni
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56039266
T1 Chapter 63. Collagens, Elastic Fibers, and Other Extracellular Matrix Proteins of the Dermis
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56039266
RD 2024/04/19
AB |PrintCollagens,  Elastic  Fibers  and  Other  Extracellular  Matrix  Proteins  of  the  Dermis  at  a  GlanceThe  extracellular  matrix  (ECM)  is  a  complex  network  composed  of  a  large  number  of  components,  which  determines  tissue  stiffness,  compliance,  and  resilience.ECM  proteins  (i.e.,  collagens,  proteoglycans,  glycoproteins)  consist  of  structural  domains  with  different  biological  functions.ECM  signals  control  cell  differentiation,  polarity,  migration,  survival,  and  expression  of  specific  genes.There  are  many  ECM-associated  heritable  diseases.  The  molecular  mechanisms  responsible  for  the  resulting  phenotypes  are  often  complex  and  involve  several  different  cellular  pathways.The  dynamic  balance  between  ECM  synthesis  and  degradation  is  critical  for  many  acquired  disease  processes,  i.e.,  tumor  invasion  and  metastasis,  fibrosis,  and  inflammatory  pathologies.