RT Book, Section
A1 Rao, Caroline L.
A1 Hall, Russell P.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56038321
T1 Chapter 58. Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56038321
RD 2024/04/23
AB |PrintLinear  Immunoglobulin  A  Dermatosis  at  a  GlanceRare  blistering  disease  with  onset  typically  after  fourth  decade  of  life.Linear  band  of  immunoglobulin  A  at  the  dermal–epidermal  basement  membrane.Clinical  presentations  may  mimic  dermatitis  herpetiformis,  bullous  pemphigoid,  and  cicatricial  pemphigoid.May  occur  in  association  with  many  drugs,  including  vancomycin.May  occur  in  association  with  inflammatory  bowel  diseases  but  only  rarely  associated  with  gluten  sensitive  enteropathy.Rarely  seen  in  association  with  malignancy,  specifically  lymphoid.Histology  shows  subepidermal  collection  of  neutrophils  at  the  basement  membrane,  often  collecting  in  papillary  tips  with  subepidermal  blisters.Most  patients  respond  dramatically  to  treatment  with  dapsone;  some  require  adjunctive  systemic  corticosteroids.Prognosis  variable  with  both  spontaneous  remissions  and  long-standing  disease.