RT Book, Section
A1 Culton, Donna A.
A1 Liu, Zhi
A1 Diaz, Luis A.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56037796
T1 Chapter 56. Bullous Pemphigoid
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56037796
RD 2024/04/25
AB |PrintBullous  Pemphigoid  at  a  GlanceUsually  occurs  in  elderly  patients.Yearly  mortality  varies  from  6%  to  40%.Pruritic  urticarial  lesions  and  tense  large  blisters.  Oral  mucous  membrane  erosions  in  minority  of  patients.Skin  pathology  shows  subepidermal  blisters  with  eosinophils.Direct  immunofluorescence  shows  immunoglobulin  (Ig)  G  and  C3  at  epidermal  basement  membrane  of  perilesional  skin,  indirect  immunofluorescence  shows  IgG  antibasement  membrane  autoantibodies  in  the  serum.The  autoantigens  BPAg1e  and  the  BP180  are  proteins  of  the  keratinocyte  hemidesmosome,  a  basal  cell–basement  membrane  adhesion  structure.Therapy  includes  topical  and  systemic  corticosteroids  and  immunosuppressives.