RT Book, Section
A1 Amado, Antoine
A1 Sood, Apra
A1 Taylor, James S.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56034835
T1 Chapter 48. Irritant Contact Dermatitis
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56034835
RD 2024/04/24
AB |PrintIrritant  Contact  Dermatitis  at  a  GlanceIrritant  contact  dermatitis  (ICD)  is  a  nonimmunologic  inflammation  of  the  skin  caused  by  contact  with  a  chemical,  physical,  or  biologic  agent.Up  to  80%  percent  of  contact  dermatitis  is  irritant  and  is  commonly  related  to  occupation.The  most  important  exogenous  factor  for  ICD  is  the  inherent  toxicity  of  the  chemical  for  human  skin.Endogenous  factors,  such  as  skin  barrier  function  and  preexisting  dermatitis,  play  an  important  role  in  the  pathogenesis  of  ICD.Atopic  dermatitis  is  a  major  risk  factor  for  irritant  hand  dermatitis  because  of  impaired  barrier  function  and  a  lower  threshold  for  skin  irritation.Patch  testing  should  be  performed  in  cases  with  suspected  chronic  irritant  dermatitis  to  exclude  an  allergic  contact  dermatitis.Identification  and  avoidance  of  the  potential  irritant  is  the  mainstay  of  treatment.