RT Book, Section
A1 Coulombe, Pierre A.
A1 Miller, Stanley J.
A1 Sun, Tung-Tien
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56034230
T1 Chapter 46. Epidermal Growth and Differentiation
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56034230
RD 2024/04/24
AB |PrintEpidermal  Growth  and  Differentiation  at  a  GlanceThe  interfollicular  epidermis  is  maintained  by  a  population  of  stem  cells.Slow-cycling  stem  cells  give  rise  to  transit  amplifying  cells,  which  yield  terminally  differentiated  cells.Abnormalities  in  epidermal  stem  cells  may  be  involved  in  pathogenesis  of  skin  cancers  and  other  proliferative  epidermal  diseases.Epidermal  differentiation  is  accompanied  by  orchestrated  expression  of  keratins  and  subunits  of  cornified  envelope.Keratins  contribute  to  the  mechanical  stability  and  pliability  of  the  epidermis.Mutations  in  major  epidermal  differentiation  products  are  underlying  causes  of  important  skin  diseases.