RT Book, Section
A1 Morris, Rebecca J.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56034143
T1 Chapter 45. Epidermal Stem Cells
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56034143
RD 2024/04/23
AB |PrintEpidermal  Stem  Cells  at  a  GlanceThe  epidermis  is  a  continually  renewing  tissue  the  function  of  which  is  maintained  by  a  hierarchy  of  stem  cells,  transit  amplifying  cells,  and  terminally  differentiating  cells.In  the  proliferative  hierarchy,  stem  cells  have  the  highest  proliferative  potential.Epidermal  stem  cells  may  be  identified  by  their  functional  characteristics,  by  distinctive  cell  cycle  patterns,  or  by  characteristic  proteins.Epidermal  stem  cells  usually  exist  in  characteristic  proliferative  units  with  little  lateral  migration.The  regulation  of  epidermal  stem  cells  comprises  complex  pathways  many  of  which  are  shared  by  embryonic,  morphogenetic,  and  homeostatic  processes.Epidermal  diseases  are  associated  with  or  may  arise  from  proliferative  dysfunction  in  the  stem  cell  or  transit  amplifying  cell  compartments.Epidermal  stem  cells  are  attractive  targets  for  cell  and  gene  therapies.