RT Book, Section
A1 Leiferman, Kristin M.
A1 Beck, Lisa A.
A1 Gleich, Gerald J.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56029863
T1 Chapter 31. Regulation of the Production and Activation of Eosinophils
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56029863
RD 2024/04/19
AB |PrintEosinophils  at  a  GlanceEosinophils  are  bone  marrow-derived  cells  that  circulate  transiently  and  normally  account  for  up  to  6%  (up  to  400–600  per  mm3)  of  circulating  blood  leukocytes.Eosinophils  primarily  are  tissue  dwelling  cells,  but  only  in  certain  tissues  in  humans,  with  an  average  tissue  life  span  of  2–5  days  that  may  be  increased  with  eosinophil  survival  factors  for  up  to  14  days.As  proinflammatory  cells,  the  presence  of  eosinophils  within  most  tissues  is  associated  with  pathological  states  that  include  infections,  allergic  reactions  and  atopic  diseases,  fibrotic  disorders,  reactive  eosinophilias,  and  hypereosinophilic  syndromes.Eosinophils  play  a  role  in  innate  and  adaptive  immune  responses,  which  may  explain  why  they  are  present  in  normal,  noninflamed  tissues  such  as  the  gastrointestinal  tract  and  lymphoid  tissues.This  section  reviews  the  biologic  actions  of  eosinophils  with  particular  focus  on  what  controls  eosinophil  production,  activation,  and  tissue  trafficking.Pharmacologic  manipulation  of  eosinophil  inflammation  is  possible  as  new,  more  specific  strategies  are  emerging.