RT Book, Section
A1 Holland, Steven M.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56029801
T1 Chapter 30. Regulation of the Production and Activation of Neutrophils
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56029801
RD 2024/04/25
AB |PrintRegulation  of  the  Production  and  Activation  of  Neutrophils  at  a  GlanceHuman  bone  marrow  commits  enormous  resources  to  the  creation  of  neutrophils,  producing  approximately  1011  daily  with  a  circulating  half-life  of  approximately  7.5  hours  and  tissue  survival  for  1–2  days.Neutrophils  are  absolutely  required  for  the  prevention  of  infection  and  are  not  yet  amenable  to  significant  external  replacement  therapy.The  neutrophil  not  only  plays  a  central  role  in  host  defense,  it  can  be  responsible  for  significant  tissue  damage  as  well.The  pathophysiology  of  the  neutrophil  indicates  pathways,  which  can  be  exploited  to  enhance  protection  from  infection.  Selective  abrogation  of  those  pathways  that  are  injurious  in  certain  settings  is  also  possible.Regulation  of  neutrophil  responses  in  the  skin  is  a  major  concern.