RT Book, Section
A1 Bruch-Gerharz, Daniela
A1 Ruzicka, Thomas
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56028015
T1 Chapter 24. Pityriasis Rubra Pilaris
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56028015
RD 2024/04/19
AB |PrintPityriasis  Rubra  Pilaris  at  a  GlanceA  papulosquamous  disorder  of  unknown  etiology  that  often  progresses  to  erythroderma  and  causes  a  disabling  keratoderma  of  the  palms  and  soles.The  disease  is  subclassified  into  six  types  including  both  hereditary  and  acquired  forms.The  typical  features  of  pityriasis  rubra  pilaris  include  follicular  hyperkeratosis  and  a  reddish  orange,  scaling  dermatitis  with  islands  of  normal  skin.Confusion  with  psoriasis  presents  the  major  problem  in  diagnosis,  particularly  in  early  phases  of  the  disease.Histopathological  examination  reveals  hyperkeratosis,  alternating  vertical  and  horizontal  parakeratosis,  and  a  mild  superficial  perivascular  lymphocytic  infiltrate.No  single  therapy  is  universally  effective,  and  some  cases  do  not  respond  to  multiple  therapies.  The  most  successful  treatment  options  are  retinoids,  photochemotherapy  (PUVA),  and  antimetabolites  (methotrexate).