RT Book, Section
A1 Gudjonsson, Johann E.
A1 Elder, James T.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56025003
T1 Chapter 18. Psoriasis
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56025003
RD 2024/04/20
AB |PrintPsoriasis  at  a  GlanceWorldwide  occurrence:  Affects  2%–3%  of  Americans;  prevalence  ranges  from  0.1%  to  3%  in  various  populations.A  chronic  disorder  with  polygenic  predisposition  combined  with  triggering  environmental  factors  such  as  trauma,  infection,  or  medication.Erythematous  scaly  papules  and  plaques;  pustular  and  erythrodermic  eruptions  occur.Most  common  sites  of  involvement  are  scalp,  elbows,  knees,  hands,  feet,  trunk,  and  nails.Psoriatic  arthritis  occurs  in  10%–25%  of  patients;  pustular  and  erythrodermic  forms  may  be  associated  with  fever.Pathology  is  characterized  by  uniform  elongation  of  the  rete  ridges,  with  dilated  blood  vessels,  thinning  of  the  suprapapillary  plate,  and  intermittent  parakeratosis.  Epidermal  and  perivascular  dermal  infiltrates  of  lymphocytes,  with  neutrophils  occasionally  in  aggregates  in  the  epidermis.