RT Book, Section
A1 Ifor, R. Williams
A1 Kupper, Thomas S.
A2 Goldsmith, Lowell A.
A2 Katz, Stephen I.
A2 Gilchrest, Barbara A.
A2 Paller, Amy S.
A2 Leffell, David J.
A2 Wolff, Klaus
SR Print(0)
ID 56023189
T1 Chapter 11. Cytokines
T2 Fitzpatrick's Dermatology in General Medicine, 8e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-166904-7
LK accessmedicine.mhmedical.com/content.aspx?aid=56023189
RD 2024/04/16
AB |PrintCytokines  at  a  GlanceCytokines  are  polypeptide  mediators  that  function  in  communication  between  hematopoietic  cells  and  other  cell  types.Cytokines  often  have  multiple  biologic  activities  (pleiotropism)  and  overlapping  biologic  effects  (redundancy).Primary  cytokines,  such  as  interleukin  1  and  tumor  necrosis  factor-α,  are  sufficient  on  their  own  to  trigger  leukocyte  influx  into  tissue.Most  cytokines  signal  through  either  the  nuclear  factor-κB  or  the  Jak/STAT  signaling  pathways.Cytokine-based  therapeutics  now  in  use  include  recombinant  cytokines,  inhibitory  monoclonal  antibodies,  fusion  proteins  composed  of  cytokine  receptors  and  immunoglobulin  chains,  topical  immunomodulators  such  as  imiquimod,  and  cytokine  fusion  toxins.