RT Book, Section A1 Andersson, Karl-Erik A2 McAninch, Jack W. A2 Lue, Tom F. SR Print(0) ID 56947388 T1 Chapter 27. Neurophysiology & Pharmacology of the Lower Urinary Tract T2 Smith & Tanagho's General Urology, 18e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-162497-8 LK accessmedicine.mhmedical.com/content.aspx?aid=56947388 RD 2024/03/28 AB The bladder, in concert with the urethra and the pelvic floor, is responsible for storage and periodic expulsion of urine. The integrated function of these components of the lower urinary tract (LUT) is dependent on a complex control system in the brain, spinal cord and peripheral ganglia, and on local regulatory factors (de Groat, 2006). Dysfunction of the central nervous control systems or of the components of the LUT can produce insufficient voiding and retention of urine, or different types of urinary incontinence (mainly urgency and stress incontinence), or the symptom complex of the “overactive bladder” (OAB), characterized by urgency, frequency with or without urgency incontinence, often with nocturia (Abrams et al, 2002).