RT Book, Section A1 Hook, Edward W. A2 Klausner, Jeffrey D. A2 Hook, Edward W. SR Print(0) ID 3026375 T1 Chapter 26. Principles of Serologic Testing for Syphilis T2 CURRENT Diagnosis & Treatment of Sexually Transmitted Diseases YR 2007 FD 2007 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-145606-7 LK accessmedicine.mhmedical.com/content.aspx?aid=3026375 RD 2024/03/29 AB • Serologic tests for syphilis are the most common means for diagnosis of syphilis and the best currently available tool for evaluating response to therapy.• Serologic diagnosis of past or present syphilis infection is based on the results of two tests: a reactive nontreponemal serologic test for syphilis, confirmed by a test for syphilis based on unrelated treponemal antigens.• Testing may be complicated by atypical immunologic responses by cross-reactive antibodies leading to false-positive test results, and by difficulties in distinguishing current from past infection.