RT Book, Section A1 Pratt, Daniel S. A2 Greenberger, Norton J. A2 Blumberg, Richard S. A2 Burakoff, Robert SR Print(0) ID 55962008 T1 Chapter 51. Primary Biliary Cirrhosis T2 CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-176848-1 LK accessmedicine.mhmedical.com/content.aspx?aid=55962008 RD 2024/10/11 AB Most patients with primary biliary cirrhosis (PBC) are asymptomatic at the time of diagnosis but eventually develop symptoms, including fatigue and pruritus.Consider PBC in any patient in whom liver enzymes are elevated in a cholestatic pattern; an isolated elevated alkaline phosphatase level always requires further evaluation.Antimitochondrial antibodies have 95% sensitivity for PBC and are central to the diagnosis.