RT Book, Section
A1 Greenberger, Norton J.
A2 Greenberger, Norton J.
A2 Blumberg, Richard S.
A2 Burakoff, Robert
SR Print(0)
ID 55960176
T1 Chapter 37. Approach to the Patient with Jaundice & Abnormal Liver Tests
T2 CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-176848-1
LK accessmedicine.mhmedical.com/content.aspx?aid=55960176
RD 2024/04/20
AB Jaundice  is  most  often  caused  by  decompensation  of  preexisting  chronic  liver  disease,  alcoholic  hepatitis,  and  gallstone  disease.Careful  history,  physical  examination,  and  routine  laboratory  tests  lead  to  accurate  diagnosis  in  85%  of  patients  with  jaundice.Cirrhosis  can  be  diagnosed  on  the  basis  of  two  physical  findings  (asterixis,  ascites)  and  two  laboratory  findings  (decreased  serum  albumin  [1.6]).Dilated  intrahepatic  bile  ducts  indicate  obstruction  from  extrahepatic  causes  (stone,  structure,  tumor).Absence  of  dilated  ducts  in  jaundiced  patients  with  serum  bilirubin  >10  mg/dL  suggests  intrahepatic  cholestasis.Sepsis,  drugs,  sickle  cell  disease,  and  chronic  hepatitis  are  the  most  common  causes  of  intrahepatic  cholestasis.