RT Book, Section
A1 Bartz, Sarah
A1 Chambers, Christina
A1 Chan, Christine M.
A1 Cree-Green, Melanie
A1 Davis, Shanlee
A1 Hsu, Stephanie
A1 Sharma, Animesh
A2 Bunik, Maya
A2 Levin, Myron J.
A2 Abzug, Mark J.
A2 Schreiner, Teri L.
SR Print(0)
ID 1211985398
T1 Endocrine Disorders
T2 Current Diagnosis &amp; Treatment: Pediatrics, 27<sup>th</sup> Edition
YR 2025
FD 2025
PB McGraw Hill
PP New York, NY
SN 9781265739898
LK accessmedicine.mhmedical.com/content.aspx?aid=1211985398
RD 2025/03/25
AB The  classic  biology  concept  that  endocrine  effects  are  the  result  of  substances  secreted  into  the  blood  which  act  on  distant  target  cells  has  been  updated  to  account  for  additional  ways  in  which  hormonal  effects  occur.  Specifically,  paracrine  systems  involve  the  stimulation  or  inhibition  of  metabolic  processes  in  neighboring  cells  (eg,  within  the  pancreatic  islets  or  cartilage).  Autocrine  hormone  effects  reflect  the  action  of  hormones  on  the  same  cells  that  produced  them.  The  discoveries  of  local  production  of  ghrelin,  somatostatin,  cholecystokinin,  incretins,  and  many  other  hormones  in  the  brain  and  gut  support  the  concept  of  paracrine  and  autocrine  processes  in  these  tissues.