RT Book, Section A1 Williams, Joshua T. B. A1 Cataldi, Jessica R. A1 Daley, Matthew F. A1 O’Leary, Sean T. A2 Bunik, Maya A2 Levin, Myron J. A2 Abzug, Mark J. A2 Schreiner, Teri L. SR Print(0) ID 1211976224 T1 Immunization T2 Current Diagnosis & Treatment: Pediatrics, 27th Edition YR 2025 FD 2025 PB McGraw Hill PP New York, NY SN 9781265739898 LK accessmedicine.mhmedical.com/content.aspx?aid=1211976224 RD 2025/03/20 AB Immunization is one of the greatest public health achievements of modern times. Largely due to immunization, the annual incidences of diphtheria, paralytic poliomyelitis, measles, mumps, rubella, and Haemophilus influenzae type b (Hib) in the United States have fallen by more than 99% compared with the average annual incidences of these diseases in the 20th century. Invasive pneumococcal disease in children younger than 5 years has declined steeply since routine pneumococcal vaccination began in 2000. Similarly, rotavirus vaccination is associated with substantial declines in hospitalizations and emergency department visits for diarrheal illnesses in young children. Childhood immunization has also led, through herd immunity, to significant decreases in several infectious illnesses in adults, including pneumococcal, rotavirus, and varicella disease. The coronavirus disease 2019 (COVID-19) pandemic disrupted health care delivery and was associated with declines in routine vaccination for infants, children, and adolescents; efforts to regain these coverage losses are ongoing.