RT Book, Section
A1 Dirkx, Tonja C.
A1 Woodell, Tyler B.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
A2 Gandhi, Monica
SR Print(0)
ID 1202385192
T1 Glomerular Diseases
T2 Current Medical Diagnosis & Treatment 2024
YR 2024
FD 2024
PB McGraw-Hill Education
PP New York, NY
SN 9781265556037
LK accessmedicine.mhmedical.com/content.aspx?aid=1202385192
RD 2024/10/08
AB The  glomerulus  is  a  histologically  complex  structure  consisting  of  the  epithelial  cells  (podocytes),  basement  membrane,  capillary  endothelium,  and  mesangium.  A  variety  of  different  insults  can  occur  within  these  structures  causing  different  patterns  of  injury.  Examples  of  injuries  that  can  affect  any  or  all  of  the  constituents  of  the  glomerulus  are  (1)  overwork  injury,  as  in  CKD;  (2)  an  inflammatory  process,  such  as  SLE;  (3)  a  podocyte  protein  mutation,  as  in  hereditary  focal  segmental  glomerulosclerosis  (FSGS);  or  (4)  a  deposition  disease,  as  in  diabetes  or  amyloidosis.  Different  glomerular  patterns  of  injury  tend  to  cause  different  clinical  syndromes  or  findings,  which  may  help  narrow  the  differential  diagnosis;  however,  when  a  glomerular  disease  is  suspected,  a  kidney  biopsy  may  be  needed  to  confirm  the  diagnosis.