RT Book, Section A1 Saavedra, Arturo P. A1 Roh, Ellen K. A1 Mikailov, Anar SR Print(0) ID 1199569049 T1 Neutrophil-Mediated Diseases T2 Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology, 9e YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264278015 LK accessmedicine.mhmedical.com/content.aspx?aid=1199569049 RD 2024/03/29 AB PG is an idiopathic, either acute or chronic, severely debilitating skin disease.It is characterized by neutrophilic infiltration, destruction of tissue, and ulceration.It occurs most commonly in association with a systemic disease, especially arthritis, inflammatory bowel disease, hematologic dyscrasias, and malignancy, but may also occur alone.Characterized by the presence of painful, irregular, boggy, blue–red ulcers with undermined borders and purulent necrotic bases.It is a diagnosis of exclusion.The mainstays of treatment are immunosuppressive or immunomodulating agents.Relapses occur in most patients and there is significant morbidity.