RT Book, Section A1 Selim, Bernardo A1 Hilbert, Janet A1 Yaggi, Henry K. A2 Grippi, Michael A. A2 Antin-Ozerkis, Danielle E. A2 Dela Cruz, Charles S. A2 Kotloff, Robert M. A2 Kotton, Camille Nelson A2 Pack, Allan I. SR Print(0) ID 1195018386 T1 Principles of Noninvasive Pressure-targeted Ventilation T2 Fishman’s Pulmonary Diseases and Disorders, 6e YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781260473988 LK accessmedicine.mhmedical.com/content.aspx?aid=1195018386 RD 2025/03/24 AB Emergent technologies have provided a wide variety of noninvasive ventilation (NIV) devices and modes to deliver treatment for respiratory failure through a mask or tracheotomy, both in the acute care setting and at home. An in-depth understanding of NIV indications, modes, and settings is crucial to guarantee delivery of effective therapy. However, knowledge gaps exist in most practitioners regarding matching advanced NIV modes and settings to a patient’s unique respiratory failure pathophysiology. In this chapter we review the principles of NIV devices and modes, assess indications for its use (e.g., neuromuscular and chest wall disease, obstructive airway diseases, obesity-related respiratory failure), and review the most recent published literature, including guidelines in the application (and adjustment) of these devices during hospitalization and at home. For additional information, the reader is referred to Chapters 98, 99, and 142, in which the use of noninvasive ventilation in management of sleep-disordered breathing and the pathogenesis of hypoventilatory disorders are discussed.