RT Book, Section A1 Cohn, Lauren A2 Grippi, Michael A. A2 Antin-Ozerkis, Danielle E. A2 Dela Cruz, Charles S. A2 Kotloff, Robert M. A2 Kotton, Camille Nelson A2 Pack, Allan I. SR Print(0) ID 1194947362 T1 T Cell Responses in the Lung T2 Fishman’s Pulmonary Diseases and Disorders, 6e YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781260473988 LK accessmedicine.mhmedical.com/content.aspx?aid=1194947362 RD 2024/03/29 AB The lung is a major site of exposure to the outside world in air-breathing species. Lung immunity has developed to recognize pathogens and activate appropriate responses, to temper inflammation in response to nonpathogenic exposures, and to turn off immune responses when danger signals have been shut down. T lymphocytes play a major role in lung immunity predominantly as CD4+ and CD8+ T cells involved in adaptive immunity. A number of smaller subsets of T lymphocytes also play critical roles in early immune responses to pathogens and to stimulate adaptive immune responses. Long-lived memory CD4+ and CD8+ T cells are crucial for host protection from pathogens, but they also may drive chronic disease states such as asthma. This chapter reviews the basic biology of T lymphocytes and their relevance in the lung in health and disease.