RT Book, Section
A1 Twigg III, Homer L.
A2 Grippi, Michael A.
A2 Antin-Ozerkis, Danielle E.
A2 Dela Cruz, Charles S.
A2 Kotloff, Robert M.
A2 Kotton, Camille Nelson
A2 Pack, Allan I.
SR Print(0)
ID 1194947274
T1 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency
T2 Fishman’s Pulmonary Diseases and Disorders, 6e
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260473988
LK accessmedicine.mhmedical.com/content.aspx?aid=1194947274
RD 2024/04/25
AB Antibody-mediated,  or  humoral,  immunity  is  essential  for  host  defense  against  respiratory  pathogens.  Defects  in  humoral  immunity  are  common  and  frequently  underappreciated.  From  a  respiratory  perspective,  patients  with  impaired  humoral  immunity  are  susceptible  to  recurrent  bacterial  sinopulmonary  infections  and  bronchiectasis.  Antibody  responses  are  also  the  principal  mechanism  behind  the  efficacy  of  vaccination  against  respiratory  pathogens.  This  chapter  focuses  on  our  understanding  of  the  normal  B  cell  environment  in  the  lung,  generation  of  appropriate  antibody  responses  after  antigenic  challenge,  disease  states  associated  with  impaired  lung  humoral  immunity,  and  the  pulmonary  response  to  vaccination.