RT Book, Section
A1 Traber, Katrina E.
A1 Mizgerd, Joseph P.
A1 Center, David M.
A2 Grippi, Michael A.
A2 Antin-Ozerkis, Danielle E.
A2 Dela Cruz, Charles S.
A2 Kotloff, Robert M.
A2 Kotton, Camille Nelson
A2 Pack, Allan I.
SR Print(0)
ID 1194947040
T1 Macrophages and Lymphocytes in the Lung
T2 Fishman’s Pulmonary Diseases and Disorders, 6e
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260473988
LK accessmedicine.mhmedical.com/content.aspx?aid=1194947040
RD 2024/04/24
AB This  chapter  describes  the  macrophage  and  lymphocyte  populations  present  in  the  lung,  in  both  the  absence  and  presence  of  inflammatory  stimuli.  This  distinction  may  be  artificial,  as  the  lung  actively  interfaces  with  the  aero-environment  and  thus  is  constantly  exposed  to  stimuli.  While  we  describe  the  phenotypes  themselves,  other  chapters  cover  the  inflammatory  processes  and  migratory  stimuli  that  change  the  inflammatory  cell  complexion  in  the  lung  in  disease  states.  Of  greatest  importance  is  to  note  that  there  is  marked  heterogeneity  of  cell  surface  markers,  secretory  products,  and  macrophage  and  lymphocyte  functions  in  the  lung  that,  together,  represent  the  overall  responses  to  stimuli  and  pathogens  and  the  resolution  of  inflammation.  We  defer  discussion  of  disease  states  to  other  chapters,  only  peripherally  referring  to  unique  roles  of  specific  macrophage  or  lymphocyte  subtypes  when  important  to  understanding  the  phenotypes.  Our  approach  is  to  divide  the  chapter  into  descriptions  of  leukocyte  subtypes  of  the  innate  (macrophages  and  lymphocytes)  and  adaptive  (lymphocytes)  immune  systems,  recognizing  that  there  are  many  other  ways  to  classify  the  inflammatory  cell  populations  in  the  lung.  Innate  and  adaptive  immunity  are  described  in  detail  in  other  chapters.