RT Book, Section
A1 Goldfarb, Stanley
A2 Grippi, Michael A.
A2 Antin-Ozerkis, Danielle E.
A2 Dela Cruz, Charles S.
A2 Kotloff, Robert M.
A2 Kotton, Camille Nelson
A2 Pack, Allan I.
SR Print(0)
ID 1194946749
T1 Acid–Base Balance
T2 Fishman’s Pulmonary Diseases and Disorders, 6e
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260473988
LK accessmedicine.mhmedical.com/content.aspx?aid=1194946749
RD 2024/04/25
AB Regulation  of  [H+]  is  of  crucial  importance  for  maintenance  of  normal  cellular  functions.  The  normal  [H+]  is  maintained  at  about  40  nEq/L.  When  there  is  even  a  small  change  in  the  [H+],  intracellular  proteins  gain  or  lose  H+  ions  resulting  in  alterations  in  charge  distribution  that  may  affect  molecular  structure  and  protein  function.  The  hydrogen  ion  concentration  in  bodily  fluids  is  largely  regulated  by  the  ratio  of  the  concentrations  of  carbon  dioxide  and  bicarbonate.  This  is  predicated  upon  the  relationship  demonstrated  in  the  Henderson–Hasselbalch  equation: