RT Book, Section
A1 Raby, Benjamin A.
A1 Tantisira, Kelan G.
A2 Grippi, Michael A.
A2 Antin-Ozerkis, Danielle E.
A2 Dela Cruz, Charles S.
A2 Kotloff, Robert M.
A2 Kotton, Camille Nelson
A2 Pack, Allan I.
SR Print(0)
ID 1194945826
T1 Personalized Pulmonary Medicine
T2 Fishman’s Pulmonary Diseases and Disorders, 6e
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260473988
LK accessmedicine.mhmedical.com/content.aspx?aid=1194945826
RD 2024/04/25
AB Since  the  first  draft  sequences  of  the  human  genome  were  completed  in  2001,1,2  medical  research  has  increasingly  focused  on  the  utilization  of  genetic  and  genomic  profiling  in  the  prediction  of  disease  susceptibility  and  natural  history,  as  well  as  drug  response  and  drug  development.  Personalized  medicine,  aka  “precision”  medicine,  can  be  defined  as  an  approach  to  medicine  in  which  medical  decisions  are  tailored  to  the  individual  patient.  In  theory,  in  patients  with  established  disease,  personalized  medicine  will  make  health  care  more  efficacious,  more  affordable,  and  safer  by  avoiding  costly  and  prolonged  trial-and-error  approaches,  unwanted  therapeutic  side  effects,  and  diminished  treatment  efficacy.  In  preclinical  settings  where  an  individual’s  molecular  profile  could  be  used  to  estimate  their  risk  of  disease,  precision  medicine  can  be  used  to  triage  patients  for  more  vigilant  screening  to  identify  disease  presence  before  clinical  indications  and  symptoms  appear  or  to  initiate  preventative  therapies.  Thus,  personalized  medicine  enhances  the  focus  on  preventive  medicine  at  the  primary,  secondary,  and  tertiary  levels.  Fully  realized,  personalized  medicine  has  the  potential  to  facilitate  early  diagnosis  and/or  prevention  of  disease  and  selection  of  optimal  therapeutic  choices  with  minimal  attendant  side  effects  for  established  disease  states.  The  potential  benefits,  from  both  a  financial  and  quality  of  life  perspective,  are  enormous.