RT Book, Section
A1 Ferkol, Thomas W.
A1 Dickinson, John D.
A1 Dickey, Burton F.
A2 Grippi, Michael A.
A2 Antin-Ozerkis, Danielle E.
A2 Dela Cruz, Charles S.
A2 Kotloff, Robert M.
A2 Kotton, Camille Nelson
A2 Pack, Allan I.
SR Print(0)
ID 1194945575
T1 Mucociliary Clearance
T2 Fishman’s Pulmonary Diseases and Disorders, 6e
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260473988
LK accessmedicine.mhmedical.com/content.aspx?aid=1194945575
RD 2024/04/19
AB Mucus  forms  an  essential  barrier  that  protects  the  lungs  from  inhaled  particles,  pathogens,  and  toxicants.  However,  excessive  mucus  accumulation  contributes  to  the  pathogenesis  of  all  the  common  diseases  of  the  airways.  Therefore,  understanding  airway  mucus  function  and  dysfunction  is  important  for  pulmonary  medicine.  The  airway  mucus  barrier  is  mobile,  continually  propelled  in  a  proximal  direction  by  ciliary  beating.  Ciliary  dysfunction  causes  disease  both  because  of  the  failure  to  clear  xenobiotics  from  the  lungs  and  by  causing  mucus  accumulation.  Mucus  and  ciliary  biology  will  be  considered  together  in  this  chapter  as  they  interact  to  achieve,  or  fail  to  achieve,  airway  clearance.