RT Book, Section A1 Cardoso, Wellington V. A1 Yang, Ying A1 Lu, Jining A2 Grippi, Michael A. A2 Antin-Ozerkis, Danielle E. A2 Dela Cruz, Charles S. A2 Kotloff, Robert M. A2 Kotton, Camille Nelson A2 Pack, Allan I. SR Print(0) ID 1194945395 T1 Molecular Regulation of Lung Development T2 Fishman’s Pulmonary Diseases and Disorders, 6e YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781260473988 LK accessmedicine.mhmedical.com/content.aspx?aid=1194945395 RD 2025/03/24 AB This chapter focuses on the mechanisms that control the development of the respiratory system from specification of the progenitors of the primordial lung to the formation of the definitive alveoli. The respiratory system is characterized not only by its major diversity in cellular phenotypes, but also by its complex 3D architecture in both the airway and alveolar compartments designed to conduct air and facilitate gas exchange. Its network of conduits comprises the trachea and extrapulmonary and intrapulmonary airways formed by multiple generations of branching epithelial tubules.