RT Book, Section A1 Ragueneau-Majlessi, Isabelle A1 Yu, Jingjing A1 Isoherranen, Nina A2 Brunton, Laurence L. A2 Knollmann, Björn C. SR Print(0) ID 1193237254 T1 Design and Optimization of Dosage Regimens: Pharmacokinetic Data T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264258079 LK accessmedicine.mhmedical.com/content.aspx?aid=1193237254 RD 2024/03/29 AB This appendix provides a summary of basic pharmacokinetic information pertaining to small-molecule drugs that are in common clinical use and are delivered to the systemic circulation by parenteral or nonparenteral administration. Because of space limitations, this list cannot be exhaustive. Drugs designed exclusively for topical administration and not significantly absorbed into the bloodstream (e.g., ophthalmic and some dermal applications) are not included. A few other selection criteria have influenced the makeup of the list, but, in general, the authors have tried to include one or more representative drugs in each of the therapeutic areas in this text, based on distinct mechanism(s) of action. In some instances, drugs may be excluded because pharmacokinetics are not relevant to their therapeutic dosing regimen design. An obvious case is when drug efficacy is not apparently correlated with drug concentration in a reversible fashion (e.g., some cytotoxic anticancer drugs). In some instances, sufficient pharmacokinetic data are not available.