RT Book, Section
A1 Hill, Matthew N.
A1 Mackie, Ken
A2 Brunton, Laurence L.
A2 Knollmann, Björn C.
SR Print(0)
ID 1193231463
T1 Cannabinoids
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264258079
LK accessmedicine.mhmedical.com/content.aspx?aid=1193231463
RD 2024/04/20
AB The  psychoactive  and  medicinal  properties  of  Cannabis  species  have  been  appreciated  for  millennia.  However,  only  recently  have  we  developed  an  understanding  of  the  compounds  present  in  cannabis  that  produce  these  effects.  The  primary  psychoactive  compounds  in  cannabis  are  the  phytocannabinoids,  which  are  meroterpenoids  typically  synthesized  from  olivetolic  acid  and  geranyl  pyrophosphate.  Δ9-Tetrahydrocannabinol  (THC)  is  the  phytocannabinoid  responsible  for  the  characteristic  psychoactivity  of  Cannabis.  Another  major  phytocannabinoid,  cannabidiol  (CBD),  may  have  distinct  therapeutic  benefits.  The  effects  of  other  phytocannabinoids  are  less  well  understood.  THC  produces  its  effects  by  engaging  the  endocannabinoid  system,  an  endogenous  signaling  system  comprised  of  endogenous  cannabinoids  (endocannabinoids),  endocannabinoid  receptors,  and  the  enzymes  responsible  for  endocannabinoid  synthesis  and  degradation.  The  endocannabinoid  system  is  widespread  throughout  the  body  and  is  involved  in  regulation  of  stress,  pain,  reward,  metabolism,  and  inflammation,  among  other  physiological  actions.