RT Book, Section A1 Ignatius, Elisa H. A1 Dooley, Kelly E. A2 Brunton, Laurence L. A2 Knollmann, Björn C. SR Print(0) ID 1193240800 T1 Chemotherapy of Tuberculosis and Nontuberculous Mycobacteria, Including Leprosy T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264258079 LK accessmedicine.mhmedical.com/content.aspx?aid=1193240800 RD 2024/10/14 AB Mycobacteria have caused epic diseases: Tuberculosis (TB) and leprosy have terrorized humankind since antiquity, and TB is thought to have killed one in seven of humans who have ever lived. Although the burden of leprosy has decreased, TB surpassed human immunodeficiency virus (HIV) as the leading infectious disease killer in 2014, and nontuberculous mycobacteria (NTM) are a growing threat in certain populations (Winthrop et al., 2020). Mycobacterium abscessus, a species of NTM, is especially devastating because of its tenacity, lack of response to combination antibiotics, and nearly universal propensity to develop acquired drug resistance. These distinct mycobacterial infections continue to be difficult to treat, owing mainly to three natural barriers: