RT Book, Section
A1 Smollin, Craig
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193161943
T1 Salicylates Overdose
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193161943
RD 2024/04/23
AB Salicylates  (aspirin,  methyl  salicylate,  bismuth  subsalicylate,  etc)  are  found  in  a  variety  of  over-the-counter  and  prescription  medications.  Salicylates  uncouple  cellular  oxidative  phosphorylation,  resulting  in  anaerobic  metabolism  and  excessive  production  of  lactic  acid  and  heat,  and  they  also  interfere  with  several  Krebs  cycle  enzymes.  A  single  ingestion  of  more  than  200  mg/kg  of  salicylate  is  likely  to  produce  significant  acute  intoxication.  Poisoning  may  also  occur  as  a  result  of  chronic  excessive  dosing  over  several  days.  Although  the  half-life  of  salicylate  is  2–3  hours  after  small  doses,  it  may  increase  to  20  hours  or  more  in  patients  with  intoxication.