RT Book, Section A1 Ursem, Carling A1 McQuaid, Kenneth R. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1193162539 T1 Carcinoma of the Anus T2 Current Medical Diagnosis & Treatment 2023 YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264687343 LK accessmedicine.mhmedical.com/content.aspx?aid=1193162539 RD 2024/04/19 AB The anal canal is lined from its proximal to distal extent by columnar, transitional, and non-keratinized squamous epithelium, which merges at the anal verge with the keratinized perianal skin.Cancers arising from the mucosa of the anal canal are relatively rare, comprising only 2% of all GI malignancies. Anal carcinoma occurred in an estimated 8590 patients in the United States in 2020, more commonly in women than men (2:1 ratio). Squamous cell carcinomas (SCC) make up the majority of anal cancers; adenocarcinomas account for the remainder but are uncommon.