RT Book, Section
A1 Smollin, Craig
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193161826
T1 Methanol & Ethylene Glycol Poisoning
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193161826
RD 2024/04/24
AB Methanol  (wood  alcohol)  is  commonly  found  in  a  variety  of  products,  including  solvents,  duplicating  fluids,  record  cleaning  solutions,  and  paint  removers.  It  is  sometimes  ingested  intentionally  by  patients  with  alcohol  use  disorder  as  a  substitute  for  ethanol  and  may  also  be  found  as  a  contaminant  in  bootleg  whiskey.  Ethylene  glycol  is  the  major  constituent  in  most  antifreeze  compounds.  The  toxicity  of  both  agents  is  caused  by  metabolism  to  highly  toxic  organic  acids—methanol  to  formic  acid;  ethylene  glycol  to  glycolic  and  oxalic  acids.  Diethylene  glycol  is  a  nephrotoxic  solvent  that  has  been  improperly  substituted  for  glycerin  in  various  liquid  medications  (cough  syrup,  teething  medicine,  acetaminophen),  causing  numerous  deaths  in  Haiti,  Panama,  and  Nigeria.