RT Book, Section
A1 Smollin, Craig
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193161756
T1 Isoniazid Overdose
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193161756
RD 2024/04/19
AB Isoniazid  (INH)  is  an  antibiotic  used  mainly  in  the  treatment  and  prevention  of  tuberculosis.  It  may  cause  hepatitis  with  long-term  use,  especially  in  patients  with  alcohol  use  disorder  and  older  adults.  It  produces  acute  toxic  effects  by  competing  with  pyridoxal  5-phosphate,  resulting  in  lowered  brain  gamma-aminobutyric  acid  (GABA)  levels.  Acute  ingestion  of  as  little  as  1.5–2  g  of  INH  can  cause  toxicity,  and  severe  poisoning  is  likely  to  occur  after  ingestion  of  more  than  80–100  mg/kg.