RT Book, Section
A1 Brown, Jill
A1 Shvartsman, Katerina
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193153692
T1 Effects of Exposure to Diethylstilbestrol in Utero
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193153692
RD 2024/04/25
AB Between  1947  and  1971,  diethylstilbestrol  (DES)  was  widely  used  in  the  United  States  for  diabetic  women  during  pregnancy  and  to  treat  threatened  abortion.  It  is  estimated  that  at  least  2–3  million  fetuses  were  exposed.  A  relationship  between  fetal  DES  exposure  and  clear  cell  carcinoma  of  the  vagina  was  later  discovered,  and  several  other  related  anomalies  have  since  been  noted.  In  one-third  of  all  exposed  women,  there  are  changes  in  the  vagina  (adenosis,  septa),  cervix  (deformities  and  hypoplasia  of  the  vaginal  portion  of  the  cervix),  or  uterus  (T-shaped  cavity)  (eFigure  18–19).