RT Book, Section A1 Saunders, Katherine H. A1 Igel, Leon I. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1193133757 T1 Vitamin E Toxicity T2 Current Medical Diagnosis & Treatment 2023 YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264687343 LK accessmedicine.mhmedical.com/content.aspx?aid=1193133757 RD 2023/12/10 AB Clinical trials have suggested an increase in all-cause mortality with high dose (greater than 400 IU/day) vitamin E supplements. Large doses of vitamin E can also increase the vitamin K requirement and result in bleeding in patients taking oral anticoagulants.