RT Book, Section A1 Douglas, Vanja C. A1 Aminoff, Michael J. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1193128511 T1 Transient Ischemic Attacks T2 Current Medical Diagnosis & Treatment 2023 YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264687343 LK accessmedicine.mhmedical.com/content.aspx?aid=1193128511 RD 2024/03/29 AB Key Clinical Updates in Transient Ischemic AttacksDual antiplatelet therapy with aspirin and clopidogrel for 90 days after a TIA or stroke due to 70–99% stenosis of an intracranial artery is recommended.The left atrial appendage is the source of embolism in most patients with atrial fibrillation. Several randomized trials showed percutaneous left atrial appendage closure was equivalent to anticoagulation in preventing stroke and systemic embolization, and several devices are approved for this indication in the United States and Europe. The procedure should be considered in patients with a contraindication to long-term anticoagulation, although short-term anticoagulation (45 days) followed by dual antiplatelet therapy (4.5 months) and then indefinite aspirin monotherapy is usually necessary after device placement.Kleindorfer DO et al. 2021 Stroke. [PMID: 34024117]