RT Book, Section
A1 Masharani, Umesh
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193133371
T1 Hypoglycemia Due to Insulin Receptor Antibodies
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193133371
RD 2024/10/06
AB Hypoglycemia  due  to  insulin  receptor  autoantibodies  is  an  extremely  rare  syndrome;  most  cases  have  occurred  in  women  often  with  a  history  of  autoimmune  disease.  Almost  all  of  these  patients  have  also  had  episodes  of  insulin-resistant  diabetes  and  acanthosis  nigricans.  Their  hypoglycemia  may  be  either  fasting  or  postprandial  and  is  often  severe  and  is  attributed  to  an  agonistic  action  of  the  antibody  on  the  insulin  receptor.  Balance  between  the  antagonistic  and  agonistic  effects  of  the  antibodies  determines  whether  insulin-resistant  diabetes  or  hypoglycemia  occurs.  Hypoglycemia  was  found  to  respond  to  corticosteroid  therapy  but  not  to  plasmapheresis  or  immunosuppression.