RT Book, Section A1 Leavitt, Andrew D. A1 Price, Erika Leemann A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1193158953 T1 Other Causes of Bleeding T2 Current Medical Diagnosis & Treatment 2023 YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264687343 LK accessmedicine.mhmedical.com/content.aspx?aid=1193158953 RD 2024/03/28 AB Occasionally, abnormalities of the vasculature and integument may lead to bleeding despite normal hemostasis; congenital or acquired disorders may be causative. Congenital abnormalities include Ehlers-Danlos syndrome, osteogenesis imperfecta, hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) (see Chapter 40), and Marfan syndrome. Acquired disorders include integument thinning due to prolonged corticosteroid administration or normal aging, amyloidosis, vasculitis, and scurvy (acquired defects). The bleeding time often is prolonged. The bleeding time reflects the integrity of the vasculature (which is abnormal in collagen synthesis disorders) in addition to activity of platelets and coagulation factors. If possible, treatment of the underlying condition should be pursued, but if this is not possible or feasible (ie, congenital syndromes), globally hemostatic agents such as antifibrinolytic agents or DDAVP can be considered for treatment of bleeding.