RT Book, Section
A1 Dirkx, Tonja C.
A1 Woodell, Tyler B.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193127776
T1 The Kidney & Aging
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193127776
RD 2024/04/25
AB After  40  years  of  age,  GFR  declines  annually  by  an  average  rate  of  0.8  mL/min/1.73  m2  (though  some  older  patients  show  little  or  no  change)  and  is  accompanied  by  a  decline  in  renal  mass  that  spares  medulla  relative  to  cortex.  In  an  attempt  to  maintain  GFR,  renal  blood  flow  decreases,  causing  a  resultant  increase  in  arteriolar  resistance  and  increased  filtration  fraction.  Serum  creatinine  values  may  remain  relatively  constant  if  muscle  mass  decreases  in  parallel  with  the  decrease  in  GFR;  a  stable  creatinine  in  the  face  of  significant  weight  loss  suggests  progression  of  kidney  disease.