RT Book, Section A1 Dirkx, Tonja C. A1 Woodell, Tyler B. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1193126657 T1 Kidney Biopsy T2 Current Medical Diagnosis & Treatment 2023 YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264687343 LK accessmedicine.mhmedical.com/content.aspx?aid=1193126657 RD 2024/04/19 AB Indications for percutaneous needle biopsy include (1) unexplained decline in GFR; (2) unexplained proteinuria or hematuria, or both; (3) previously identified and treated lesions to guide future therapy; (4) systemic diseases associated with kidney dysfunction, such as SLE, anti-GBM disease, and granulomatosis with polyangiitis (eFigure 22–3); and (5) kidney transplant dysfunction, to evaluate for transplant rejection or other abnormalities. Kidney biopsies should only be performed if the results will influence the treatment plan or facilitate discussion about prognosis. Relative contraindications include a solitary or ectopic kidney (exception for transplant allografts), horseshoe kidney, ESKD, congenital anomalies, and multiple cysts. Absolute contraindications include an uncorrected bleeding disorder; severe uncontrolled hypertension; renal infection or neoplasm; hydronephrosis; or uncooperative patients, including those who are unable to lie flat for the procedure.