RT Book, Section
A1 Damon, Lloyd E.
A1 Andreadis, Charalambos Babis
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193158132
T1 Unstable Hemoglobins
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193158132
RD 2024/09/18
AB Unstable  hemoglobins  are  prone  to  oxidative  denaturation  even  in  the  presence  of  a  normal  G6PD  system.  The  disorder  is  autosomal  dominant  and  of  variable  severity.  Most  patients  have  a  mild  chronic  hemolytic  anemia  with  splenomegaly,  mild  jaundice,  and  pigment  (calcium  bilirubinate)  gallstones.  Less  severely  affected  patients  are  not  anemic  except  under  conditions  of  oxidative  stress.