RT Book, Section
A1 Damon, Lloyd E.
A1 Andreadis, Charalambos Babis
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193158025
T1 Pure Red Blood Cell Aplasia
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193158025
RD 2024/04/25
AB Acquired  pure  RBC  aplasia  is  rare.  It  is  an  autoimmune  disease  mediated  by  T  lymphocytes  or  by  an  IgG  antibody  against  erythroid  precursors  in  the  bone  marrow  or  both.  In  adults,  the  disease  is  usually  idiopathic.  However,  cases  have  been  seen  in  association  with  SLE,  chronic  lymphocytic  leukemia  (CLL),  lymphomas,  or  thymoma.  Some  medications  (phenytoin,  chloramphenicol)  may  cause  RBC  aplasia.  Rarely,  anti-erythropoietin  antibodies  cause  pure  RBC  aplasia  in  patients  who  are  treated  with  recombinant  erythropoietin.  Transient  episodes  of  RBC  aplasia  are  probably  common  in  response  to  viral  infections,  especially  parvovirus  infections.  However,  these  acute  episodes  will  go  unrecognized  unless  the  patient  has  a  chronic  hemolytic  disorder  or  a  chronic  immunocompromised  state,  in  which  case  the  hematocrit  may  fall  precipitously.