RT Book, Section
A1 Manno, Rebecca L.
A1 Yazdany, Jinoos
A1 Tarrant, Teresa K.
A1 Kwan, Mildred
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193126269
T1 Primary Immunodeficiency Disorders in Adults
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193126269
RD 2024/04/24
AB Primary  immunologic  deficiency  diseases  are  estimated  to  affect  1  in  4000  individuals;  most  are  genetically  determined  and  present  in  early  childhood.  Nonetheless,  several  important  immunodeficiency  disorders  present  in  adulthood,  most  notably  the  antibody  deficiency  syndromes:  selective  IgA  deficiency,  common  variable  immunodeficiency  (CVID),  and  specific  (functional)  antibody  deficiency  (Table  20–14).  Antibody  deficiency  predisposes  patients  to  recurrent  serious  bacterial  infections,  particularly  of  the  respiratory  tract,  including  refractory  chronic  rhinosinusitis,  bronchitis,  pneumonia,  and  bronchiectasis.  Patients  are  most  susceptible  to  infections  with  encapsulated  bacteria  (eg,  Haemophilus  influenzae  type  b,  Streptococcus  pneumoniae,  Neisseriameningitides).  However,  any  part  of  the  innate  or  adaptive  immune  system  can  be  defective,  which  results  in  infections  with  different  spectra  of  organisms  depending  on  the  severity  of  the  immune  defect.