RT Book, Section
A1 Tarrant, Teresa K.
A1 Kwan, Mildred
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193126152
T1 Allergic & Immunologic Disorders
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193126152
RD 2024/04/25
AB Allergy  is  an  immune-mediated  hypersensitivity  reaction  to  a  foreign  antigen  manifest  by  tissue  inflammation  and  organ  dysfunction.  The  clinical  expression  of  allergic  IgE-mediated  disease  depends  on  antigen  exposure  and  host  susceptibility  manifesting  as  atopy.  Atopic  patients  have  an  immunologic  predisposition  to  several  disorders:  allergic  rhinitis  (see  Chapter  8),  allergic  asthma  (see  Chapter  9),  atopic  dermatitis  (see  Chapter  6),  and  IgE-mediated  food  allergies.  Although  these  disorders  tend  to  aggregate  in  atopic  families,  each  of  these  disorders  may  occur  in  individuals  without  personal  or  familial  history  of  atopic  disease.  In  addition,  many  mast  cell–  and  IgE-dependent  disorders  (eg,  many  drug  and  chemical  sensitivities,  eosinophilic  disorders,  mast  cell  stability  syndromes,  chronic  urticaria)  occur  with  a  similar  incidence  in  atopic  and  non-atopic  persons.